Giammarco, S., Chiusolo, P., Di Giovanni, A., Metafuni, E., Sica, S., Iavarone, F., et al.
Treatment-induced oral mucositis (OM) is a pathological process characterized by mucosal damage, from mild inflammation to deep ulcerations and affecting one or more parts of the gastrointestinal tract as a consequence of chemotherapy and radiation therapy. The major complications in haematological malignancies patients (pts) submitted to HSCT are infections, in particular due to E.Coli, P. Aeruginosa and Candida. Treatment of OM is only palliative. Several studies showed the successful treatment of the symptoms associated to OM with the strain of Lactobacillus brevis, due to the process of microflora manipulation.